Mendoza is 1,037 kilometres from Buenos Aires (14 hours by bus) and 380 kilometres from Santiago, Chile (6 hours by bus). Mendoza also has an International Airport. It takes less than 2 hours to fly from Buenos Aires and less than 1 hour from Santiago, Chile.

The Mendoza public transport system includes buses, trolleybuses and taxi-cabs. The trolleybuses are more comfortable than the city buses, but are slower and not as widespread.

Mendoza developed because of its position on one of the Trans-Andean Railways where the Argentine and Chilean rail lines link. This line is currently out of use, but there are plans to restore it in summer 2007.

There is a break-of-gauge at Mendoza – and the other at Los Andes, Chile – between the broad gauge line (1676 mm) from the capital and the meter gauge of the Central Trans-Andean Railway. This Trans-Andean Railway was also a rack railway in some sections.