Manaus is a cosmopolitan city, and, because of its location next to the Amazon rain forest, it attracts a substantial number of Brazilian and foreign tourists, who can find plenty of boat and land trips into the surrounding jungle. A great diversity of wildlife can be found even in the surroundings of Manaus. It is also home to one of the most endangered primates in Brazil, the Pied tamarin.

The Teatro Amazonas, an opera house built in 1896, is a notable landmark of Manaus, reflecting the massive wealth of the turn of the century rubber boom. The theatre was prominently featured Werner Herzog's 1982 film Fitzcarraldo. The exuberant interior of this 1896 opera house, completed after 15 years, contains crystal chandeliers, wrought-iron banisters, and Italian frescoes, as well as a museum.

"The meeting of the waters," the confluence of the Negro and Solimões rivers which extends for about 9 km, is a very sought-after trip that lasts an average of 6 hours and gives visitors the opportunity to experience firsthand the final episode of formation of the Amazon river.

About 18 km from downtown is Ponta Negra beach, a neighbourhood that has a beachfront and popular nightlife area. A luxurious hotel is located at the west end of Ponta Negra; its small but very interesting zoo and orchid greenhouse as well as preserved woods and beach are open to public visitation.

The CIGS Zoo (military zoo for rescued animals), which doubles as an army training center, also is located in the neighbourhood and houses a few hundred endemic and native amazonian species of mammals, reptiles, and birds.

The Mercado Adolpho Lisboa, founded in 1882, is the city's oldest marketplace, trading in fruit, vegetables, and especially fish. It's a copy of the Les Halles market of Paris. Other interesting historical sites include the customs building, of mixed styles and medieval inspiration; the Rio Negro Palace cultural center; and the Justice Palace, right next to the Amazonas Opera House.

Manaus has also many large parks with native forest preservation areas, such as the Bosque da Ciência and Parque do Mindú. The largest urban forest in the world is located within Federal University of Amazonas, which was founded in January 17, 1909 and is the oldest federal university of Brazil.

The city has a busy cultural calendar throughout the year, including the Opera, Theater, Jazz and Cinema festivals, as well as Boi Manaus (usually held around Manaus' anniversary on the 24th of October), which is a great celebration of Northern Brazilian culture through Boi-Bumbá music.